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KMID : 1009020170150020190
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Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 2 p.190 ~ p.193
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Low-dose Clozapine-induced Seizure: A Case Report
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Bolu Abdullah
Akarsu Suleyman
Pan Erdal
Aydemir Emre
Oznur Taner
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Abstract
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Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.
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KEYWORD
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Clozapine, Adverse effects, Seizures, Safety
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